Psychodermatology of the Female: Hormones, Skin and Mental Health Across the Lifespan

Abstract

Psychodermatology examines the bidirectional relationship between mental health and skin disease, offering an integrated approach to understanding the psychosocial impacts of dermatologic conditions. Intricate interactions between physiological stressors, immune system responses and hormonal signals are central to this relationship. For women, hormonal transitions throughout the lifespan play a critical role in modulating both skin pathophysiology and mental health. In this narrative review, we discuss how hormonal milestones, such as menstruation and pregnancy, contribute to cutaneous manifestations. We examine these fluctuations through the lens of the brain–skin axis and the Neuro-Immuno-Cutaneous-Endocrine (NICE) network, which incorporates hormonal, immune and neural signals within the skin. Additionally, we draw attention to common psychiatric comorbidities that present alongside skin disorders, including depression, anxiety and body dysmorphia. By focusing on these challenges, we hope to highlight the unique psychosocial burdens faced by women with visible skin conditions and advocate for integrative treatment approaches. Ultimately, this review underscores the need for gender-specific care that addresses the full spectrum of women's psychodermatologic health.