Juvenile chronic arthritis, chronic iridocyclitis, and reactivity to histones

Abstract

We know that autoimmune diseases of rheumatology in children and adults are different and their laboratory features are not the same. Histones are basic DNA binding proteins and antibodies in them may occur in juvenile chronic arthritis. The complication of chronic iridocyclitis is probably genetically linked and is uncommon if juvenile chronic arthritis begins after the age of 5 years. Production of antibodies to histones may be a further characteristic of this.