Low-intensity tower climbing resistance exercise reduces experimentally induced atopic dermatitis in mice

Abstract

In general, exercise can help improve overall health and prevent dis-eases. However, individuals with atopic dermatitis (AD) often lose the desire for physical exercise owing to itching caused by sweating. In the present study, we have evaluated the effect of low-intensity tower climbing resistance exercise (TCRE) on Dermatophagoides farinae ex-tract (DFE; house dust mite extract)- and 2,4-dinitrochlorobenzene-in-duced AD-like skin lesions in a BALB/c model. Histopathological exam-ination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells in the ears. TCRE downregulated serum Ig levels and suppressed mRNA expression of pro-inflammatory cyto-kines in the ear tissue, and reduced the size and weight of draining lymph nodes (dLNs) and nondraining lymph nodes (ndLNs), along with expres-sion of pro-inflammatory cytokines in CD4+ T cells from dLNs and ndLNs. Taken together, we showed that low-intensity TCRE reduced AD symp-toms. These results will help improve treatment of AD, and will be of in-terest to dermatologists as well as to patients with AD.