A fluorescent light-up probe as an inhibitor of intracellular β-tryptase

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Abstract

A pyrene-functionalized peptidic inhibitor 1 binds to and inhibits β-tryptase in a non-competitive and reversible manner even in cells. Upon protein binding a fluorescence increase of the two pyrene fluorophores is observed which allows using 1 as a fluorescent light-up probe for this enzyme. © 2014 The Partner Organisations.

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Wang, Q., Shi, X., Zhu, X., Ehlers, M., Wu, J., & Schmuck, C. (2014). A fluorescent light-up probe as an inhibitor of intracellular β-tryptase. Chemical Communications, 50(46), 6120–6122. https://doi.org/10.1039/c4cc02208d

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