Paclitaxel Particle Distribution 3 Months After Drug-Coated Balloon Treatment ― Zemporshe ® Angioscopy Assessment ―

Abstract

diately after DCB deployment, and again at 3 months later. Angioscopy immediately after DCB deployment showed that the paclitaxel particles were tightly adhered to the vascular wall (Figure). 1 Angioscopy 3 months after DCB treatment showed small paclitaxel particles still remaining, although there was no clustering or protrusion of paclitaxel particles, and the amount of paclitaxel seemed to have decreased substantially (Figure). Paclitaxel tissue concentration was decreased to 10% at 30 days in a healthy swine model according to the In.Pact Admiral DCB group. 2 This is the first report to demonstrate D rug distribution over time after treatment with a drug-coated balloon (DCB) has not been reported in the clinical setting. We observed the distribution of paclitaxel particles on the vascular wall after treatment with DCB (IN.PACT TM Admiral TM drug-coated balloon) using an electronic high-resolution angioscope (Zemporshe ® , OVALIS, Osaka, Japan). A 78-year old woman underwent endovascular therapy for the chronic total occlusion of the right mid-superficial femoral artery. Zemporshe angioscopy was performed immediately after pre-dilatation with a balloon, then imme-Figure. (Left) Angioscopy after drug-coated balloon (DCB) deployment showing a homogeneous distribution of paclitaxel particles. (Right) At 3 months after DCB treatment, paclitaxel particles still remained on the vascular wall.