EZH2 mutations increase the heterogeneity of chromatin states in lymphoma

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Abstract

A recent study in PLoS Biology used simultaneous measurements of histone modifications in single cells to reveal that EZH2 gain-of-function mutations profoundly reprogram chromatin states in B-cell lymphoma, while also increasing their cell–cell heterogeneity.

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Holoch, D., & Margueron, R. (2025). EZH2 mutations increase the heterogeneity of chromatin states in lymphoma. PLOS Biology, 23(6 JUNE). https://doi.org/10.1371/journal.pbio.3003211

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