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Glycosylated Polyene Macrolides Kill Fungi via a Conserved Sterol Sponge Mechanism of Action

ACS Central Science (2021) 7(5) 706-708
DOI: 10.1021/acscentsci.1c00520
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Abstract

Systematic analysis of glycosylated polyene macrolides expands the biosynthetic gene cluster and chemical space and supports the sterol sponge mechanism of antifungal action.

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Revie, N. M., & Cowen, L. E. (2021). Glycosylated Polyene Macrolides Kill Fungi via a Conserved Sterol Sponge Mechanism of Action. ACS Central Science, 7(5), 706–708. https://doi.org/10.1021/acscentsci.1c00520

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