Heme oxygenase-1 system and gastrointestinal inflammation: A short review

Abstract

Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/ bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 byyypharmacological means or usinggene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. © 2011 Baishideng. All rights reserved.