[FeFe]-Hydrogenase Cyanide Ligands Derived from S-Adenosylmethionine- Dependent Cleavage of Tyrosine

Abstract

"Chemical Equation Presented" What's your poison? Hydrogenases catalyze the reversible formation of dihydrogen from two electrons and two protons. The maturation of the [FeFe]-hydrogenase active-site cofactor (H cluster) requires three gene products, HydE, HydF, and HydG. Cyanide has been characterized as one of the products of tyrosine cleavage by the S-adenosylmethionine-dependent enzyme HydC, clarifying its role in H-cluster biosynthesis. DOA = deoxyadenosine. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.