An induction heating device using planar coil with high amplitude alternating magnetic fields for magnetic hyperthermia

Abstract

BACKGROUND: Induction heating devices using the induction coil and magnetic nanoparticles (MNPs) are the way that the magnetic hyperthermia is heading. OBJECTIVE: To facilitate the induction heating of in vivo magnetic nanoparticles in hyperthermia experiments on large animals. METHODS: An induction heating device using a planar coil was designed with a magnetic field frequency of 328 kHz. The coil's magnetic field distribution and the device's induction heating performance on different concentrations of magnetic nanoparticles were measured. RESULTS: The alternating magnetic field produced in the axis position 165 mm away from the coil center is 40 Gs in amplitude; magnetic nanoparticles with a concentration higher than 80 mg. mL-1 can be heated up rapidly. CONCLUSION: Our results demonstrate that the device can be applied not only to in vitro and in small animal experiments of magnetic hyperthermia using MNPs, but also in large animal experiments.