Dissemination of bla NDM -harboring plasmids in carbapenem-resistant and hypervirulent Klebsiella pneumoniae

Abstract

The appearance of plasmids carrying bla NDM and the rise of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have significantly escalated the public health risk associated with Carbapenem-resistant Klebsiella pneumoniae (CRKP). In this study, we described the resistance rates, virulence factors, and molecular epidemiology of 59 CRKP isolated from patients at a tertiary hospital in China from 2019 to 2021. Beyond this, we also assessed the characteristics of bla NDM -harboring plasmids and their dissemination patterns among CRKP, especially some CR-hvKP. Our research contributes to the field of bla NDM dissemination studies, prompting researchers to formulate strict measures to prevent and control the development of bla NDM -harboring plasmids, which is instrumental in the clinical development of targeted treatment plans.