In vitro activities of the new antitubercular agents PA-824 and BTZ043 against Nocardia brasiliensis

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Abstract

The in vitro activity of PA-824 and BTZ043 against 30 Nocardia brasiliensis isolates was tested. The MIC 50 and MIC 90 values for PA-824 were both >64 μg/ml. The same values for BTZ043 were 0.125 and 0.250 μg/ml. Given the MIC values for benzothiazinone (BTZ) compounds, we consider them good candidates to be tested in vivo against N. brasiliensis. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

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Vera-Cabrera, L., Campos-Rivera, M. P., Gonzalez-Martinez, N. A., Ocampo-Candiani, J., & Cole, S. T. (2012). In vitro activities of the new antitubercular agents PA-824 and BTZ043 against Nocardia brasiliensis. Antimicrobial Agents and Chemotherapy, 56(7), 3984–3985. https://doi.org/10.1128/AAC.00115-12

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