Sex Differences In Central Inflammatory Pain Sensitization Are Associated With Differential Expression Of Glycine Receptors And Glp-1 At The Spinal Cord

Abstract

Background: Females have higher inflammatory pain representation. However, sex differences incentral pain sensitization and the regulation of nociceptive response to peripheral inflammation remain unclear. The central pain sensitization is mediated by inhibitory neurotransmission and glial cell activity dysregulation where spinal glycine and GLP-1 receptors have described play a critical role. Objectives: The aim of this study was to compare the mechanical withdrawal nociceptive threshold with spinal glycine receptor subunits and GLP-1 expression in adult male and female rats after inflammatory Hypersensitivity. Methods: Sex differences in inflammatory nociception were evaluated before and after intraplantar hindpaw Zymosan A injection in Sprague-Dawley rats. Mechanical paw withdrawal thresholds were tested using von