Prognostic importance of ultrasound BI-RADS classification in breast cancer patients

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Abstract

Objective: We investigated the prognostic importance of pre-operative Breast Imaging Reporting and Data System classification in ultrasound imaging. Methods: Histopathological differences and disease-free survival were analyzed in Breast Imaging Reporting and Data System classification subgroups. Univariate and multivariate analyses were used to identify the prognostic factors. Results: We identified 531 invasive breast cancer patients eligible for this study. Most patients classified as Breast Imaging Reporting and Data System 5 had large tumors and a higher rate of lymph node metastasis. However, hormonal receptor or HER-2 status did not differ according to Breast Imaging Reporting and Data System classification. During a median post-operative follow-up of 42.0 months, 43 patientswere diagnosed with a disease-specific event. Disease-free survivalwas significantly lower in patients with Breast Imaging Reporting and Data System 5 than in patients with Breast Imaging Reporting and Data System 3-4. Subgroup analysis of patients with invasive breast cancer of Stage I showed that Breast Imaging Reporting and Data System 5 was an independent negative prognostic indicator of disease-free survival (hazard ratio 9.195; 95% confidence interval, 1.175-71.955; P = 0.035). Conclusions: Breast Imaging Reporting and Data System classification might be considered as prognostic factors especially in Stage I breast cancer. Further confirmatory studies are needed.

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Kim, J. Y., Jung, E. J., Park, T., Jeong, S. H., Jeong, C. Y., Ju, Y. T., … Choi, S. K. (2015). Prognostic importance of ultrasound BI-RADS classification in breast cancer patients. Japanese Journal of Clinical Oncology, 45(5), 411–415. https://doi.org/10.1093/jjco/hyv018

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