Efficient multiplication of a Semliki Forest virus chimera containing Sindbis virus spikes

  • Smyth J
  • Suomalainen M
  • Garoff H
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Abstract

Using the Semliki Forest virus (SFV) and Sindbis virus (SIN) cDNAs we have constructed recombinants in which the spike genes were exchanged. Analyses of expression showed that the SFV/SIN(spike) RNA directed efficient assembly of infectious virus, whereas the reciprocal SIN/SFV(spike) RNA was completely unable to assemble virus. This was apparently due to a defective capsid-spike interaction.

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Smyth, J., Suomalainen, M., & Garoff, H. (1997). Efficient multiplication of a Semliki Forest virus chimera containing Sindbis virus spikes. Journal of Virology, 71(1), 818–823. https://doi.org/10.1128/jvi.71.1.818-823.1997

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