mSphere of Influence: a Systematic Approach To Dissect Virulence Traits in Candida albicans

Abstract

J. Christian Pérez studies the interplay between Candida albicans and the mammalian host. In this mSphere of Influence article, he reflects on how “Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity” (S. M. Noble, S. French, L. A. Kohn, V. J. Christian Pérez studies the interplay between Candida albicans and the mammalian host. In this mSphere of Influence article, he reflects on how “Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity” (S. M. Noble, S. French, L. A. Kohn, V. Chen, et al., Nat Genet 42:590–598, 2010, https://doi.org/10.1038/ng.605 ) provided tools and a blueprint for open-ended genetic screens in an organism that had been a challenge for genetic manipulation.