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Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling

Cell Systems (2020) 11(3) 300-314.e8
DOI: 10.1016/j.cels.2020.08.007
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Abstract

This study demonstrates that transcriptional variability of the toll-like receptor signaling is constrained by mean mRNA responses through gene-specific modulation of transcriptional bursting.

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Bagnall, J., Rowe, W., Alachkar, N., Roberts, J., England, H., Clark, C., … Paszek, P. (2020). Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling. Cell Systems, 11(3), 300-314.e8. https://doi.org/10.1016/j.cels.2020.08.007

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