Preparation, characterization, and analytical application of ramipril membrane-based ion-selective electrode

Abstract

The fabrication and electrochemical evaluation of two PVC membrane–based Ion–Selective electrodes responsive for ramipril drug have been proposed. The sensitive membranes were prepared using ramipril–phosphomolibdate and ramipril–tetraphenylborate ion–pair complexes as electroactive sensing materials in plasticized PVC support. The electrodes based on these materials provide near–Nernestian response (sensitivity of 53±0.5–54±0.5 mV/concentration decade) covering the concentration range of 1.0×10-2–1.0×10-5 mol L–1 with a detection limit of 3.0×10-6–4.0×10-6 mol L-1. The suggested electrodes have been successfully used in the determination of ramipril drug in some pharmaceutical formulations using direct potentiometry with average recovery of >96% and mean standard deviation of <3% (n = 5).