GATM gene variants and statin myopathy risk

Abstract

Mangravite et al. identified six expression quantitative loci (eQTLs) that interacted with simvastatin exposure by using 480 lymphoblastoid cell lines exposed to β-hydroxy simvastatin acid in vitro. One of these SNPs (rs9806699) within the glycine amidinotransferase (GATM) gene was shown to have an association with statin-induced myopathy in two independent cohorts (n = 172 myopathy cases), conferring a protective effect (odds ratio = 0.61, 95% confidence interval = 0.39-0.95, P = 0.03). Our genotyping results from statin myopathy patients do not appear to replicate this finding. There is a Reply to this Brief Communication Arising by Mangravite, L. M. et al. Nature 513, http://dx.doi.org/10.1038/nature13630 (2014).