Étude physico-chimique, spectres de vibration et structure du sulfaméthoxazole

Abstract

Two polymorphic and one solvate forms of sulfamethaxozole have been identified and characterized using various thermal and spectral methods. The crystal structure of form II has been solved and compared with that of form I recently published: the lengths of the intermolecular H bonds mainly differentiate the two polymorphic forms. An assignment of the fundamental vibrations of the amine, amide, and sulfone groups involved in the H intermolecular bonds has been proposed from the analysis of the Raman and infrared spectra.