Re-replication of SV40 minichromosomes is inhibited at the stage of chain elongation

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Abstract

The template activities of protein-free SV40 DNA and SV40 minichromosomes for DNA re-repllcatlon are compared in In vitro replication assays. Density substitution experiments and two-dimensional gel electrophoresis show that protein-free DNA can replicate for at least two cycles whereas salt-treated minichromosomes replicate only once. Re-repllcatlon of minichromosomes is blocked at the stage of replicatlve chain elongation suggesting that repll-catively assembled chromatin has structural features that prevent a second round of replication. © 1994 Oxford University Press.

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Krude, T., Winter, A., & Knippers, R. (1994). Re-replication of SV40 minichromosomes is inhibited at the stage of chain elongation. Nucleic Acids Research, 22(24), 5265–5270. https://doi.org/10.1093/nar/22.24.5265

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