Preoperative preparation of patients with coronary artery disease and comorbidity of chronic obstructive lung disease to scheduled coronary artery bypass graft surgery

Abstract

We aimed to assess an impact of different prehabilitation schemes on a risk of postoperative cardiorespiratory complications after coronary artery bypass graft surgery (CABG) in patients with coronary artery disease (CAD) and comorbid chronic obstructive pulmonary disease (COPD). Methods. Two groups of patients with CAD and comorbid COPD who were planned for CABG were recruited in the study using the pairwise testing. A criterion of difference was the treatment with tiotropium/olodaterol (Tio/Olo) as one of prehabilitation components. An occurrence of postoperative cardiorespiratory complications was analyzed according to prehabilitation schemes used. Results. The patients with CAD + COPD treated with Tio/Olo during 12.4 ± 5.4 days prior to CABG surgery demonstrated improvement in clinical and laboratory parameters characterizing the severity of COPD just before surgical coronary revascularization. A risk of postoperative cardiovascular and respiratory complications was higher in patients not receiving bronchodilator therapy before the surgery.