Comparison of serum 25-hydroxyVitamin D levels in patients with malignant and benign gynaecological disease

Abstract

Background/Aim: Many studies have shown an antiproliferative, anti-inflammatory, anti-angiogenetic, and apoptosis-inducing effect of Vitamin D. A Vitamin D deficiency has been associated with an increased risk for different types of cancer. This study examined Vitamin D 25(OH)D levels in gynaecological cancers in comparison with benign gynaecological diseases. Patients and Methods: Serum 25(OH)D levels in 688 gynaecological patients (488 with malignant, 200 with a benign gynaecological disease) were assayed between 2009 and 2015 using an electrochemiluminescence immunoassay. Results: In total, the 25(OH)D levels in cancer patients were lower, but not significantly lower than those in cancer-free patients. Significant results were shown regarding seasonal effects for patients with breast-, endometrial and ovarian cancer. No significant effects occurred with regard to menopause status, nicotine, or grade in relation to 25(OH)D levels. Conclusion: 25(OH)D levels seem to influence gynaecological cancers.