Diagnostic and Therapeutic Challenges in Disseminated Mycobacterium colombiense Infection Caused by Interferon-γNeutralizing Autoantibodies

Abstract

Adult-onset immunodeficiency due to interferon-γ-neutralizing autoantibodies (nIFNγ-AutoAbs) can remain underdiagnosed. We present a case of severe Mycobacterium colombiense infection with nIFNγ-AutoAbs. To ensure early diagnosis, clinicians should have a high index of suspicion in patients of Asian descent with opportunistic infections and perform QuantiFERON-TB assay for disease screening.