Immuno-polymeric nanoparticles by Diels-Alder chemistry

Abstract

(Figure Presented) Hitting the target: Self-assembled polymeric nanoparticles from an amphiphilic copolymer were prepared with furan groups on the outer polyethylene glycol corona that were accessible for Diels-Alder reactions with maleimide-functionalized antibodies for the preparation of immuno-nanoparticles (see picture). The simple and clean coupling methodology allows facile modification of nanoparticles for use in targeted delivery to cancer cells. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.