Nonlinear photodynamic therapy. Saturation of a photochemical dose by photosensitizer bleaching

Abstract

Photodynamic therapy with total photobleaching of a photosensitizer was studied theoretically. The possibilities of having constant therapeutic dose within a large extent of a tissue and even of obtaining the maximal dose at a particular depth were considered. The use of both surface irradiation or interstitial irradiation were evaluated. © The Royal Society of Chemistry and Owner Societies 2003.