Quinone oxidoreductase 2 serum level that affecting the psychotic disorders of methamphetamine abusers

Abstract

Background: Some evidence suggests that genetic factors contribute to susceptibility to drug abuse such as methamphetamin and that dopamine-quinone produced by dopamine might be involved in the mechanism of symptoms associated with psychotic methamphetamine (MAP). Quinone detoxification is catalyzed by a group of proteins, namely quinone oxidoreductase (NQO). In this study we analyzed serum NQO2 levels by examining ELISA Sandwich in clients who used methamphetamine. Methods: This research is a Case-Control to determine the contribution of NQO2 to the emergence of psychotic disorders due to methamphetamine abuse. The case group is residents who consume methamphetamine with psychotic characteristics, while the control group is clients who consume methamphetamine without psychotic characteristics Results: The mean value of NQO2 gene protein in the Elisa Sandwich examination for the case group was lower than the value of the control group (1,246 < 3,657). The t test showed the value of sig (Equal variances not assumed) = 0,000 that value is less than 0.05 (<0.05), this shows the difference in the value of content protein NQO2 between the case group and the control group. Then the cut-off point of the Receiver Operating Characteristic (ROC) curve in this study is recommended statistically between 1,960 and 2,165, meaning that if the expression value of protein content > 2.165 then the potential for psychotic suffering is great, on the other hand if < 1.960, the potential is small for suffering from psychotics. Conclusion: The protein content of the NQO2 gene in the Elisa Sandwich examination between the case and control groups is different, the case group is lower than the control. While the CURVE ROC (Receiver Operating Characteristic) Cut-Off value is recommended statistically between 1,960 and 2,165.