Effect of Type-2 Diabetes Mellitus in Retinopathy Patients on MDA, SOD Activity and its Correlation with HbA1c

Abstract

Diabetic retinopathy (DR) is a metabolic disorder of the retina and one of the common problemsof Type-2 diabetes mellitus (T-2DM) causing visual loss even at teen ages. In this research article, oxidativestress was the main cause due to reactive oxygen species (ROS) generation at hyperglycemic state andbecome as the focus point of this study to describe (DR) complication onset. The present study wasconducted to compare three groups: T-2DM with complication, T-2DM without complication and control group.For this purpose, number of the individuals participating in this study were n=110 as subject along with T-2DM patients with complication n=50, T-2DM patients without complication n=50 and rest n=10 are taken ascontrol/ normoglycemic individuals. T-2DM patients with/without complication have TAG level is lower thannormoglycemic/ control. An observed value of (HbA1c%) glycosylated or glycated hemoglobin type A1cconcentration of T2DM with complication group was highest (9.63%) amongst the examined groups. T-2DMwith complication has lowest SOD activity (660.96 U/gHb) but the malondialdehyde (MDA) level was foundto be higher (5.96 μmol/L) amongst studied groups. Lowest plasma TAG, and higher plasma MDA levelindicate the presence of oxidative stress in T2D with/without complications. SOD activity was decreased dueto the protein glycation and the surplus level of lipid detoxification especially found in T-2DM cases. Goodglycemic control counteracts the response of Lipid peroxidation usually occurs in hyperglycemic state.