A general method for the n-alkylation of thioamides.

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Abstract

Thioamides are N-alkylated in a two-step procedure: (i) Reaction with an aldehyde and benzotriazole yields an adduct which is (ii) reduced to the N-alkylthiomide by NaBH4. © 1988.

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Katritzky, A. R., & Drewniak, M. (1988). A general method for the n-alkylation of thioamides. Tetrahedron Letters, 29(15), 1755–1758. https://doi.org/10.1016/S0040-4039(00)82034-1

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