The assessment of 5-aminolevulinic acid photodynamic therapy in glioblastomas

Abstract

Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) has emerged as a promising strategy in the treatment of various cancers, particularly gliomas. The biosynthesis of prodrug 5-ALA plays a pivotal role in the heme production pathway of Protoporphyrin IX (PpIX), and understanding this molecular process offers significant insights into cellular physiology and therapeutic potential. This review highlights the clinical applications of 5-ALA in PDT, underscoring the translational impact of foundational research on its biosynthesis. The search, performed on PubMed and Web of Science, included both in vivo clinical studies and in vitro preclinical studies. The findings of this review emphasize the expanding potential for novel therapeutic strategies, driven by an enhanced understanding of 5-ALA biosynthesis and its application in PDT, offering a promising future for medical advancements in cancer treatment.