Physico-chemical and microbiological comparison of nystatin, amphotericin A And amphotericin B, and structure of amphotericin A

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Abstract

Two polyene antibiotics, nystatin and amphotericin A, were compared by physico-chemical and microbiological methods. The two antibiotics were found to have thesame molecular weight, 926, by plasma desorption and electron-impact Ms. However, 13C Nmr spectrometry and Hplc studies indicated that the two molecules are different. The 200 Mhz Nmr studies indicated a chemical environment of 24 carbons of amphotericin A identical with that of the carbons of amphotericin and nystatin. © 1985, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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Aszalos, A., Bax, A., Burlinson, N., Roller, P., & Mcneal, C. (1985). Physico-chemical and microbiological comparison of nystatin, amphotericin A And amphotericin B, and structure of amphotericin A. The Journal of Antibiotics, 38(12), 1699–1713. https://doi.org/10.7164/antibiotics.38.1699

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