OILS AS PENETRATION ENHANCERS FOR IMPROVED TRANSDERMAL DRUG DELIVERY: A REVIEW

Abstract

Transdermal drug delivery system is the most suitable system for delivering the drugs with shorter half-life and poor solubility. It improves the drug safety and therapeutic efficacy as the drug delivery through it occurs in a controlled manner. Interpretation of the biochemical composition and barrier function exerted by the stratum corneum has lead for the exploration of different sources for improving the percutaneous absorption. Skin is the suitable site for drug administration for local and systemic actions. Penetration enhancement is an improving technology that leads to the increase in the count of drugs for TDDS. The present review reports the role of Natural oils in enhancing the permeation of drugs through skin because of possessing different features like natural origin, favorable penetration enhancement and partitioning action in the skin by the oils. Various natural oils, their classification and influence as penetration enhancers were discussed in this study.