Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells

Abstract

Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation. © 2008 The Japan Society of Human Genetics and Springer.