Total synthesis of diplodialides C and D

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Abstract

A highly convergent, stereoselective total synthesis of diplodialides C and D is described. The protocol involves the use of regioselective ring opening of a chiral epoxide, sequential double alkylation of 1,3-dithiane with a bromide and a chiral epoxide, hydroboration and Yamaguchi macrolactonisation as key steps.

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Ramanujan, V., & Kumar, C. N. S. S. P. (2018). Total synthesis of diplodialides C and D. Arkivoc, 2018(7), 332–340. https://doi.org/10.24820/ark.5550190.p010.703

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