Microwave assisted synthesis, spectral correlation and antimicrobial evaluation of some aryl imines

Abstract

A series of aryl imines have been synthesized by SiO2-H3PO4 catalyzed microwave assisted condensation of amine and aldehyde under solvent-free conditions. The yield of the imines has been found to be more than 80%. The purity of all imines has been checked using their physical constants and spectral data as published earlier in literature. The UV λmax(nm), infrared νC=N(cm-1), NMR δ(ppm) of C-H and C=N spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The antimicrobial activities of all imines have been studied using Bauer-Kirby method.