Impairment of neural mechanosensitivity in the Long COVID haulers

Abstract

Background: The aim of this study was to evaluate and characterize the alteration in mechanosensitivity in Long COVID haulers as well as its impact on patients’ functionality and quality of life. Research design and methods: In this study there were two groups: a group of Long COVID haulers and a group of healthy controls matched for age and sex. The mechanosensitivity clinical profile and peripheral nerve mechanosensitivity were evaluated. The mechanosensitivity clinical profile included the functionality and quality of life (World Health Organization Disability Assessment Schedule 2.0, Patient-Reported Outcomes Measurement Information System, EuroQol-5 Dimensions) and neural mechanosensitivity (Leeds Assessment of Neuropathic Symptoms and Signs). The peripheral nerve mechanosensitivity included neurodynamic tests (median, radial, ulnar, slump test and straight leg raise). Results: A total of 64 patients were included in the study (Long COVID haulers group n = 33, healthy controls group n = 31). Long COVID haulers group obtained significantly worse results in functionality (p < 0.001), quality of life (p < 0.001), neural mechanosensitivity (p < 0.001) and peripheral nerve mechanosensitivity (p < 0.001). Conclusions: Long COVID haulers have significant alterations in neural mechanosensitivity, contributing to a greater degree of functional impairment and poorer quality of life.