A study of DNA ploidy pattern, proliferation index and PCNA in duodenal carcinoma

Abstract

12 cases of duodenal carcinoma were studied for nuclear DNA ploidy patterns, the proliferation index (PI), proliferating cell nuclear antigen (PCNA) positive score (1=0∼25%, 2=26∼50%, 3=51∼75%, 4=76∼100%) and PCNA positive rate. DNA aneuploidy was observed in 9 cases (75%) and PCNA staining was positive in 11 cases (91.6%). DNA ploidy patterns, PI, PCNA positive scores and positive rates were not related to each other. No relationship DNA ploidy patterns for PCNA positive scores and PCNA positive rates could be found. The relationship between PI and PCNA positive score was found not to be significant (P<0.10). PI was revealed to correlate significantly (P<0.05) to PCNA positive rate. © 1992, The Japanese Society of Gastroenterology. All rights reserved.