Evidence of Beneficial Effects of Strict Glycemic Control on Diabetic Vascular Complications-A Prospective Study with Artificial Devices

Abstract

Shichiri, M., Kawamori, R., Gobiya, Y., Kikuchi, M., Bando, K. and Abe, H. Evidence of Beneficial Effects of Strict Glycemic Control on Diabetic Vascular Complications——A Prospective Study with Artificial Devices Tohoku J. exp. Med., 1983, 141, Suppl., 719-722——This prospective study was undertaken to examine whether glycemic normalization could have beneficial on the course of diabetic vascular complications in 6 insulin-dependent diabetics. A significant amelioration of glycemic regulation was achieved by intensive glycemie control with artificial devices and multiple injections for 3 months, which also resulted in an improvement in conduction velocity, a regression in retionvascular permeability and a decrease in urinary total protein excretion. These results indicate that even after short-term treatment, glycemic near-normalization can have a beneficial effect on the early stage of diabetic vascular complications.————diabetes mellitcs, vascular complication, prospective study. © 1983, Tohoku University Medical Press. All rights reserved.