Dietary calcium intake is associated with serum highsensitivity Creactive protein level in the general Japanese population

Abstract

The beneficial effects of dietary calcium intake on highsensitivity Creactive protein levels, a risk factor of cardiovascular disease, have not been fully elucidated. This study investigated the associa tions between dietary calcium intake and serum highsensitivity Creactive protein levels in the general Japanese population. We analyzed the data of 2,019 subjects (1,194 men and 825 women) aged 35 to 69 years in a crosssectional study of the Japan Multi Institutional Collaborative Cohort Study. Nutrients intake including calcium were estimated using a validated foodfrequency ques tionnaire. Analysis using a general linear model revealed that dietary calcium intake was inversely associated with serum high sensitivity Creactive protein levels (p for trend <0.001) after adjustment for age, sex, research group, leisuretime physical activity, smoking habit, drinking habit, dietary intakes (energy, dietary fiber, saturated fatty acids and vitamin D) and meno pausal status. The association was slightly attenuated after addi tional adjustment for body mass index; however, remained significant (p for trend = 0.008). There were no significant inter actions between dietary calcium intakes and sex, body mass index, or vitamin D intake for highsensitivity Creactive protein levels. This study have demonstrated that dietary calcium intake was inversely associated with serum highsensitivity Creactive protein levels in the general population.