Abstract
Straight chain compounds having a phenylisoserine unit and an oxetane ring at the α- and ω- position, respectively as extremely simplified analogues of taxol were prepared. None of these compounds showed promising tubulin inhibitory activity.
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APA
Fuji, K., Watanabe, Y., Ohtsubo, T., Nuruzzaman, M., Hamajima, Y., & Kohno, M. (1999). Synthesis of extremely simplified compounds possessing the key pharmacophore units of taxol, phenylisoserine and oxetane moieties. Chemical and Pharmaceutical Bulletin, 47(9), 1334–1337. https://doi.org/10.1248/cpb.47.1334
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