2-Methoxy-4-vinylphenol attenuates migration of human pancreatic cancer cells via blockade of FAK and AKT signaling

Abstract

Background/Aim: No effective therapeutics have yet been developed for pancreatic cancer. 2-Methoxy-4-vinyl phenol (2M4VP), a member of the class of phenols, has been demonstrated to have anti-inflammatory properties and cause cell cycle arrest making it an attractive candidate drug for the treatment of pancreatic cancer. Materials and Methods: The effects of 2M4VP were examined in Panc-1 and SNU-213 human pancreatic cancer cells. Results: 2M4VP had anticancer effects on pancreatic cancer cell lines, Panc-1 and SNU-213. 2M4VP reduced the viability of Panc-1 cells by inhibiting the expression of the cell nuclear antigen (PCNA) protein. 2M4VP also suppressed the migratory activity of both cell lines. In addition, treatment with 2M4VP effectively decreased the phosphorylation of Focal Adhesion Kinase (FAK) and AKT. Conclusion: 2M4VP might be used as a pancreatic cancer treatment supplement.