Persisting concentrating and second gas effects on oxygenation during N2O anaesthesia

Abstract

Theoretical modelling predicts that the concentrating effect of nitrous oxide (N2O) uptake on alveolar oxygenation is a persisting phenomenon at typical levels of ventilation - perfusion (V/Q) inhomogeneity under anaesthesia. We sought clinical confirmation of this in 20 anaesthetised patients. Arterial oxygen pressure (Pa O2 was measured after a minimum of 30 min of relaxant general anaesthesia with an inspired oxygen (F1O2) of 30%. Patients were randomly allocated to two groups. The intervention group had N2O introduced following baseline blood gas measurements, and the control group continued breathing an identical F1 O2 in nitrogen (N2. The primary outcome variable was change in PaO2. Mean (SD) in Pa O2 was increased by 1.80 (1.80) kPa after receiving a mean of 47.5 min of N2O compared with baseline conditions breathing O2/N2 (p = 0.01). This change was significantly greater (p = 0.03) than that in the control group: + 0.09 (1.37) kPa, p = 0.83 and confirms the presence of significant persisting concentrating and second gas effects. © 2006 The Authors Journal compilation 2006 The Association of Anaesthetists of Great Britain and Ireland.