Sparteine oxidation polymorphism in Greenlanders living in Denmark.

Abstract

Sparteine oxidation appeared to be polymorphic in 185 healthy Greenlanders living in Denmark. Six subjects (3.2%) were phenotyped as poor metabolizers (PM) and 179 subjects as extensive metabolizers (EM). The metabolic ratio (MR) between sparteine and 2‐ + 5‐dehydrosparteine in a 12 h urine sample ranged from 0.06‐3.12 in EM and from 30‐480 in PM. The excretion of dehydrosparteines accounted for less than 2.2% of the dose in PM and ranged from 5.6%‐63% in EM. The urinary recovery (% of dose) of sparteine, 2‐dehydrosparteine and total sparteine + dehydrosparteines was lower in Greenlander EM than in Danish EM (Brosen et al., 1985). Incomplete urine collection in a substantial proportion of the Greenlanders could explain these discrepancies. 1986 The British Pharmacological Society