Extracts of Turmeric (Curcuma longa L.) as a Potential ‎Biocontrol of Multidrug-Resistant‏ ‏Acinetobacter baumannii

Abstract

Nosocomial infections with Acinetobacter baumannii are increasing every day, making treatment with traditional antibiotics more complicated. This work aimed to investigate the antibacterial activity of Curcuma longa extracts against carbapenem-resistant isolates of A. baumannii. A  total of  90 samples (Sputum, n=40 and Urine, n=50) were collected and biochemically identified via Vitek -2 system. Ten isolates were identified as A. baumannii (10/90; 11.1%). (10/90; 100 %) of isolates identified were multi drug resistance (MDR). Curcuma longa  extracts aqueous and/or ethyl acetate of, exhibited a significant MBC value varying from 43.75 to 50.83 mg ml-1 against A. baumannii isolates (A1, A2, A3, A5, A6, and A8), respectively. Within isolates A1 and A8, ethanol extracts revealed MBC with significant values (30 to 70 mg ml-1) respectively. The main phytochemical compounds detected among 68 bioactive compounds in the extracts of C. longa over the GC- mass spectra analysis were Turmerone (59.42%), Beta-caryophyllene (16.66 %), Caryophyllene oxide (15.62 %), Isolongifol (12.14 %), Alpha-pinene (12.07 %), Citral (11.68 %), Curdione (11.0 %), B -Sesquiphellandrene (10.47% ), B-myrcene (8.12 %), D-Limonene (8.04 %). Bactericidal activity of C. longa against MDR A. baumannii were supported by phytochemical compounds that detected in GC-MS analysis.