C-19393 S2 and H2, new carbapenem antibiotics i. taxonomy of the producing strain, fermentation and antibacterial properties

Abstract

C-19393 S2 and H2are new carbapenem antibiotics produced by a streptomycete. The producing strain was taxonomically studied and named Streptomycesgriseus subsp. cryophilus. Cobaltous compounds were necessary for production of the antibiotics. C-19393 S2and H2showed a broad spectrum of antibacterial activities with C-19393 H2being 8~ 120 times more active than C-19393 S2. They also exhibited β-lactamase-inhibiting activities and acted synergistically with ampicillin and cefotiam against clinical isolates resistant to β-lactam antibiotics. © 1980, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.