PHYTOCHEMICAL CONSTITUENTS AND CYTOTOXIC ACTIVITY FROM Scoparia dulcis LINN OF INDONESIA ORIGIN

Abstract

Scoparia dulcis Linn is a widely distributed perennial in tropical and subtropical regions, including Indonesia. Its pharmacological properties include cytotoxic, antiproliferative, antitumor, antiviral, anticancer, antibacterial, antifungal, antidiabetic, anti-inflammatory, and antioxidant activities. Therefore, the purpose of this researchis to determine the cytotoxic effects of phytochemical constituents of Scoparia dulcis Linn grown in Indonesia. In the process, 6-methoxy benzoxazole-2-(3H)-one was separated from soluble fraction ethyl acetate (FEA) of Scoparia dulcis ethanolic extract. Furthermore, extensive NMR studies were used to determine the compound structure. Thecytotoxic activities of these compounds against MCF-7 and T47D breast cancer cell lineswere also tested. The results showed that 6-methoxy benzoxazole-2-(3H)-one had no significant effect on this cancer cell. It was concluded that this compound could be developed to be another biological activity test; hence, it is used as a lead compound.