Synthesis and Antimicrobial Activity of Coumarinyl Schiff Base Derivatives

Abstract

We have reported some novel N’-[(1)-ethylidene]-2-(6-methyl-2-oxo-2H-chromen-4-yl) acetohydrazide synthesized by conventional method. The reaction of 2-(6-methyl-2-oxo-2H-chromen-4-yl)acetohydrazide with substituted benzaldehyde in methanol as a solvent yielded a series of (7a-l). The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1 H NMR, 13 C NMR and elemental analysis. Moreover, all synthesized compounds were screened for In Vitro antimicrobial activity against the gram positive ( Staphylococcus aureus , Bacilluas subtilis ) and gram negative ( Escherichia coli , P. aeruginosa , K. pneunonae , Enterobacter ) bacterial strain. In which some the compounds show potential inhibition against the test organisms.