LIS-3 register of the acute coronary syndrome: What has changed in a "portrait" of a patient and short-term outcomes of the disease compared to LIS-1 register

Abstract

Aim. To compare a «portrait» of a patient and hospital lethality between register LIS-1 of myocardial infarction (MI) and register LIS-3 of acute coronary syndrome (ACS). Material and methods. We compared two registers held in Lubertsy town: MI register LIS-1 (2005-2007) and ACS register LIS-3 (01.11.2013-31.07.2015). LIS-1 is a retrospective study; information about patients survived and died in hospital was taken from medical histories. LIS-3 is a prospective study; data on survived patients was collected from questionnaires and medical histories, information about died ones - from medical histories. Results. «Portrait» of a patient of LIS-1 and LIS-3 registers was comparable in gender, age, history of MI, arterial hypertension, atrial fibrillation, and stroke. LIS-3 patients had diabetes mellitus more often, and on the contrary, history of ischemic heart disease (IHD) and angina pectoris - more rarely than LIS-1 patients. ACS was the first manifestation of IHD in 64% of LIS-3 register patients and 31.4% of LIS-1 register patients. Hospital lethality was 15.2% in LIS-1 register and 19.4% in LIS-3 register (p > 0.05). Hospital lethality increased in elderly patients in both registers. Atrial fibrillation increased hospital lethality risk in LIS-3 register and long-term mortality risk in LIS-1 register. History of arterial hypertension and angina pectoris re- duced hospital lethality risk in LIS-3 register. In LIS-1 register neither of these factors was significant, but left ventricular hypertrophy reduced hospital mortality risk. Conclusion. LIS-1 and LIS-3 patients were comparable in many factors, bud differed in history of IHD (31.4% in LIS-1 register, 64% in LIS-1 register) and angina pectoris. Factors associated with hospital mortality differed in the two registries.