Pyridopyrazine derivatives, process of manufacturing and use in the treatment of malignant disorders and disorders bases on pathological cell proliferations.

Abstract

The invention relates to pyrido[2,3-b]pyrazine derivs. of general formula I, to their prepn. and use as medicaments, esp. for the treatment of malignant disorders and other disorders based on pathol. cell proliferations. Compds. of formula I wherein R3 and R4 are independently NH2 and derivs., H, alkyl, C9-30 alkyl, cycloalkyl, etc.; R1, R2 and R5 are independently H, alkyl, C9-30 alkyl, cycloalkyl, heterocyclyl, etc.; are claimed. Example compd. II was prepd. by substitution of 1-(6-chloropyrido[2,3-b]pyrazin-3-yl)-3-ethylurea with p-toluidine. All the invention compds. were evaluated for their kinase inhibitory activity (some data given). [on SciFinder(R)]