Abstract
Background: The bone marrow environment secretes OPG and can thereby prevent TRAIL-induced apoptosis in multiple myeloma. Results: rhTRAIL D269H/E195R shows a decreased affinity to OPG and induces apoptosis in multiple myeloma cells in the presence of OPG. Conclusion: Apoptosis induction by rhTRAIL D269H/E195R is not inhibited by OPG. Significance: rhTRAIL D269H/E195R can be used as potential therapy for multiple myeloma. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Bosman, M. C. J., Reis, C. R., Schuringa, J. J., Vellenga, E., & Quax, W. J. (2014). Decreased affinity of recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) D269H/E195R to osteoprotegerin (OPG) overcomes trail resistance mediated by the bone microenvironment. Journal of Biological Chemistry, 289(2), 1071–1078. https://doi.org/10.1074/jbc.M113.491589
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